Donepezil and flight simulator performance: effects on retention of complex skills

Neurology. 2002 Jul 9;59(1):123-5. doi: 10.1212/wnl.59.1.123.

Abstract

We report a randomized, double-blind, parallel group, placebo-controlled study to test the effects of the acetylcholinesterase inhibitor, donepezil (5 mg/d for 30 days), on aircraft pilot performance in 18 licensed pilots with mean age of 52 years. After 30 days of treatment, the donepezil group showed greater ability to retain the capacity to perform a set of complex simulator tasks than the placebo group, p < 0.05. Donepezil appears to have beneficial effects on retention of training on complex aviation tasks in nondemented older adults.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aging
  • Aviation
  • Cholinesterase Inhibitors / administration & dosage*
  • Donepezil
  • Double-Blind Method
  • Humans
  • Indans / administration & dosage*
  • Middle Aged
  • Motor Skills / drug effects*
  • Piperidines / administration & dosage*
  • Psychomotor Performance / drug effects

Substances

  • Cholinesterase Inhibitors
  • Indans
  • Piperidines
  • Donepezil