Modular Connections between Areas V2 and V4 of Macaque Monkey Visual Cortex

Eur J Neurosci. 1989;1(5):494-506. doi: 10.1111/j.1460-9568.1989.tb00356.x.


We have studied the connections between two visual areas of macaque monkey cortex, V2 and V4, by injecting wheat-germ agglutinin horseradish peroxidase (HRP-WGA) into V4 and examining the distribution of labelled cells and terminals in V2, in relation to its characteristically striped cytochrome oxidase architecture. The cells projecting from V2 to V4 are arranged in bands and the number of bands per cycle of cytochrome oxidase stripes varies (one cycle consists of a thin stripe, a thick stripe and two interstripes). In the Type 1 connectivity pattern, there is just one band per cycle, centred over the thin stripes but normally spreading into the neighbouring interstripes. In the Type 2 connectivity pattern there are two bands per cycle, generally rather narrower and centred over the interstripes. Thick stripes are mostly free of labelled cells. The return projection from V4 to V2, whilst being concentrated in the vicinity of the labelled cells, is more diffusely distributed and invades the territory of all the stripes.