Chromosome aberrations: past, present and future

Mutat Res. 2002 Jul 25;504(1-2):3-16. doi: 10.1016/s0027-5107(02)00075-1.

Abstract

Spontaneous and induced chromosome aberrations have been studied over more than a century. The resolution of detection of aberrations has depended on the improvement of available techniques. An overview on the major high lights in this area of research, from the time of solid staining to fluorescence in situ hybridization technique is presented in this review.

Publication types

  • Review

MeSH terms

  • Alkylating Agents / pharmacology
  • Animals
  • Chromosome Aberrations* / drug effects
  • Chromosome Aberrations* / radiation effects
  • DNA Damage
  • DNA Repair
  • Drosophila / drug effects
  • Drosophila / genetics
  • Drosophila / radiation effects
  • Forecasting
  • Humans
  • In Situ Hybridization, Fluorescence
  • Neomycin / pharmacology
  • Plants / drug effects
  • Plants / genetics
  • Plants / radiation effects
  • Research / trends
  • Research Design
  • Sister Chromatid Exchange / drug effects
  • Sister Chromatid Exchange / radiation effects

Substances

  • Alkylating Agents
  • Neomycin