Toll Receptors, CD14, and Macrophage Activation and Deactivation by LPS

Microbes Infect. 2002 Jul;4(9):903-14. doi: 10.1016/s1286-4579(02)01613-1.

Abstract

This review will focus on the molecular mechanisms of macrophage activation and desensitization by bacterial lipopolysaccharide (LPS). The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / immunology*
  • Drosophila Proteins*
  • Humans
  • Immunity, Innate / immunology*
  • Lipopolysaccharide Receptors / immunology*
  • Lipopolysaccharides / immunology*
  • Macrophage Activation
  • Macrophages / immunology*
  • Membrane Glycoproteins / immunology*
  • Receptors, Cell Surface / immunology*
  • Shock, Septic / immunology
  • Shock, Septic / physiopathology
  • Signal Transduction
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Lipopolysaccharide Receptors
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors