Structural and functional analyses of bacterial lipopolysaccharides

Microbes Infect. 2002 Jul;4(9):915-26. doi: 10.1016/s1286-4579(02)01612-x.

Abstract

Bacterial lipopolysaccharides (LPSs) are powerful immunomodulators in infected hosts, and may cause endotoxic shock. Most of them share a common architecture but vary considerably in structural motifs from one genus, species, and strain to another. Cells of the innate immune response recognize evolutionarily conserved LPS molecular patterns of endotoxins and structural details thereby greatly influencing their response.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacteria / immunology*
  • Cytokines / immunology
  • Humans
  • Immunity, Innate / immunology
  • Lipopolysaccharides / chemistry*
  • Lipopolysaccharides / immunology*
  • Molecular Structure
  • Monocytes / immunology
  • Shock, Septic / immunology*
  • Signal Transduction

Substances

  • Cytokines
  • Lipopolysaccharides