doi: 10.1016/s1286-4579(02)01617-9.
VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology
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- PMID: 12106794
- DOI: 10.1016/s1286-4579(02)01617-9
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VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathology
Microbes Infect.
2002 Jul.
Free article
Abstract
African trypanosomes express a glycosylphosphatidyl inositol (GPI)-anchored variant-specific surface glycoprotein (VSG) as a protective coat. During infection, large amounts of VSG molecules are released into the circulation. Their interaction with various cells of the immune system underlies the severe infection-associated pathology. Recent results have shown that anti-GPI vaccination can prevent the occurrence of this pathology.
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