[Anti-inflammatory properties of noopept (dipeptide nootropic agent GVS-111)]

Eksp Klin Farmakol. Mar-Apr 2002;65(2):53-5.
[Article in Russian]

Abstract

It is established that single intravenous (0.5 and 5 mg/kg, p.o.) or single peroral (10, 50, 100 mg/kg) and prolonged peroral (5 mg/kg, over 10 days) administration of noopept produces a dose-dependent inhibition of the model inflammatory response to concanavaline A in CBA mice. Intravenously injected (5 mg/kg) noopept suppressed the acute nonimmune carrageenan-induced foot inflammation in rats by 62.2% within 3 h. The most pronounced antiinflammatory effect of dipeptide was observed on the model of adjuvant arthritis in rats, where the drug administered over 25 days in a daily dose of 0.5 mg/kg (i.m.) or 5 mg/kg (p.o.) significantly reduced the chronic immune inflammation (on the 12th day, by 94.0 and 74.1%, respectively). The in vitro experiments with neutrophilic leukocytes of F1(CBA.C57BL/6) mice treated with noopept in a single dose of 5 mg/kg (i.v.) showed a 5- to 6-fold suppression of the hemiluminescence stimulated by opsoinized zymosan or phorbolmyristate acetate. It is suggested that the antiinflammatory activity of noopept is probably related to its antioxidant properties.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Antioxidants / administration & dosage
  • Antioxidants / therapeutic use*
  • Arthritis, Experimental / drug therapy
  • Chronic Disease
  • Dipeptides / administration & dosage
  • Dipeptides / therapeutic use*
  • Edema / drug therapy
  • Luminescent Measurements
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Rats
  • Reactive Oxygen Species / metabolism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Dipeptides
  • Reactive Oxygen Species
  • ethyl phenylacetyl-Pro-Gly