[Fatal miliary tuberculosis during treatment with infliximab]

Ned Tijdschr Geneeskd. 2002 Jun 22;146(25):1196-9.
[Article in Dutch]


A 73-year-old woman was admitted to hospital with fever whilst under treatment with infliximab for rheumatoid arthritis. Despite repeated and specific testing, tuberculosis was only diagnosed post mortem. During infliximab therapy, latent tuberculosis can reactivate in subacute form with a possible fatal outcome. For infliximab therapy to be administered safely, the risk that the patient concerned is latently infected with tuberculosis has to be estimated beforehand; if necessary a prophylactic anti-tuberculosis treatment may be given.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antibodies, Monoclonal / adverse effects*
  • Antibodies, Monoclonal / therapeutic use
  • Antirheumatic Agents / adverse effects*
  • Antirheumatic Agents / therapeutic use
  • Arthritis, Rheumatoid / drug therapy
  • Fatal Outcome
  • Female
  • Humans
  • Infliximab
  • Tuberculosis, Miliary / etiology*


  • Antibodies, Monoclonal
  • Antirheumatic Agents
  • Infliximab