Destabilizing influences in apoptosis: sowing the seeds of IAP destruction

Cell. 2002 Jun 28;109(7):793-6. doi: 10.1016/s0092-8674(02)00802-4.

Abstract

Inhibitor of apoptosis proteins (IAPs) can block apoptosis through interactions with members of the caspase family of cysteine proteases. Recent developments suggest that ubiquitin-proteasome mediated destruction of the Drosophila IAP, DIAP1, is a key event during the initiation of programmed cell death in the fly.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis*
  • Caspases / metabolism
  • Cytochrome c Group / metabolism
  • Drosophila / cytology*
  • Drosophila / enzymology
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism*
  • Inhibitor of Apoptosis Proteins
  • Neuropeptides / metabolism
  • Peptides / metabolism
  • Ubiquitin / metabolism

Substances

  • Cytochrome c Group
  • DIAP1 protein, Drosophila
  • Drosophila Proteins
  • HID protein, Drosophila
  • Inhibitor of Apoptosis Proteins
  • Neuropeptides
  • Peptides
  • Ubiquitin
  • grim protein, Drosophila
  • rpr protein, Drosophila
  • Caspases