Characterization of Anisotropy in High Angular Resolution Diffusion-Weighted MRI

Magn Reson Med. 2002 Jun;47(6):1083-99. doi: 10.1002/mrm.10156.

Abstract

The methods of group theory are applied to the problem of characterizing the diffusion measured in high angular resolution MR experiments. This leads to a natural representation of the local diffusion in terms of spherical harmonics. In this representation, it is shown that isotropic diffusion, anisotropic diffusion from a single fiber, and anisotropic diffusion from multiple fiber directions fall into distinct and separable channels. This decomposition can be determined for any voxel without any prior information by a spherical harmonic transform, and for special cases the magnitude and orientation of the local diffusion may be determined. Moreover, non-diffusion-related asymmetries produced by experimental artifacts fall into channels distinct from the fiber channels, thereby allowing their separation and a subsequent reduction in noise from the reconstructed fibers. In the case of a single fiber, the method reduces identically to the standard diffusion tensor method. The method is applied to normal volunteer brain data collected with a stimulated echo spiral high angular resolution diffusion-weighted (HARD) acquisition.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anisotropy
  • Brain / anatomy & histology*
  • Brain / physiology
  • Diffusion
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging / methods*
  • Mathematics
  • Models, Theoretical