High headache prevalence among women with hemochromatosis: the Nord-Trøndelag health study

Ann Neurol. 2002 Jun;51(6):786-9. doi: 10.1002/ana.10209.


In this large cross-sectional population-based study, 51,272 persons responded to a headache questionnaire and were screened for hemochromatosis. Phenotypic hemochromatosis and the C282Y/C282Y genotype were both associated with an 80% increase in headache prevalence evident only among women. The reason for this association is unclear, but one may speculate that iron overload alters the threshold for triggering a headache by disturbing neuronal function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Cross-Sectional Studies
  • Female
  • Headache / epidemiology*
  • Hemochromatosis / genetics
  • Hemochromatosis / physiopathology*
  • Humans
  • Iron / metabolism
  • Male
  • Norway / epidemiology
  • Phenotype
  • Prevalence
  • Surveys and Questionnaires


  • Iron