Anaplastic T large cell lymphoma diagnosed by exfoliative cytology in a post renal transplant patient

Diagn Cytopathol. 2002 Jul;27(1):35-7. doi: 10.1002/dc.10100.


In the last two decades posttransplant lymphoproliferative disorders (PTLDs) have been recognized as a complication of organ transplantation with immunosuppression. The reported incidence of PTLDs in renal transplant patients ranges between 0.3-3% (Birkeland et al., Transplantation 1999;67:876-881). In contrast to the reported incidence of PTLDs in post bone marrow transplant, it is 1% in HLA-matched recipients and up to 20% in HLA mismatched T-cell depleted bone marrow recipients (Curtis et al., Blood 1996;94:2208-2216). In cardiac transplant recipients the reported incidence of PTLDs is between 1.8-9.8 (Mihalov et al., Clin Transplant 1996;10:248-255). PTLDs are predominately extranodal. They have varied morphologic patterns and clonality, but almost all are associated with Epstein-Barr virus (EBV). The vast majority are of B cell lineage; only about 10% are of T-cell origin. We report a T-cell anaplastic large cell lymphoma (ALCL) presenting with bilateral pleural effusion and liver involvement in a renal transplant recipient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / metabolism
  • Biopsy, Needle
  • Female
  • Humans
  • Immunohistochemistry
  • Immunosuppression Therapy / adverse effects*
  • Kidney Transplantation*
  • Liver / immunology
  • Liver / pathology
  • Liver Neoplasms / immunology
  • Liver Neoplasms / pathology
  • Lymphoma, T-Cell / etiology*
  • Lymphoma, T-Cell / immunology
  • Lymphoma, T-Cell / pathology*
  • Pleural Effusion / etiology
  • Pleural Effusion / pathology


  • Biomarkers, Tumor