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, 27 (7), 344-51

rRNA Modifications and Ribosome Function

rRNA Modifications and Ribosome Function

Wayne A Decatur et al. Trends Biochem Sci.


The development of three-dimensional maps of the modified nucleotides in the ribosomes of Escherichia coli and yeast has revealed that most (approximately 95% in E. coli and 60% in yeast) occur in functionally important regions. These include the peptidyl transferase centre, the A, P and E sites of tRNA- and mRNA binding, the polypeptide exit tunnel, and sites of subunit-subunit interaction. The correlations suggest that many ribosome functions benefit from nucleotide modification.

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