Early detection of central nervous system tuberculosis with the gen-probe nucleic Acid amplification assay: utility in an inner city hospital

Clin Infect Dis. 2002 Aug 1;35(3):339-42. doi: 10.1086/341494. Epub 2002 Jul 8.


Central nervous system tuberculosis is a serious clinical problem, the treatment of which is sometimes hampered by delayed diagnosis. We investigated the utility of the Gen-Probe nucleic acid amplification assay for the rapid diagnosis of tuberculous meningitis and as a noninvasive method of identifying intracranial tuberculoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diagnostic Techniques and Procedures
  • Gene Amplification
  • Hospitals, Urban
  • Humans
  • Mycobacterium tuberculosis / isolation & purification*
  • Polymerase Chain Reaction / methods*
  • Tuberculosis, Central Nervous System / diagnosis*
  • Tuberculosis, Central Nervous System / microbiology