Risk of Pancreatic Cancer in Relation to Alcohol Drinking, Coffee Consumption and Medical History: Findings From the Japan Collaborative Cohort Study for Evaluation of Cancer Risk

Int J Cancer. 2002 Jun 10;99(5):742-6. doi: 10.1002/ijc.10402.

Abstract

We evaluated the associations of such lifestyle factors as alcohol drinking, coffee consumption and medical history with risk of death from pancreatic cancer in a large-scale prospective cohort study [the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC study)] in Japan. Subjects were 110,792 (46,465 men and 64,327 women) inhabitants who were enrolled from 45 areas throughout Japan. At baseline, a self-administered questionnaire was used to obtain information on lifestyle factors and medical history. Cox proportional hazard models were used to calculate relative risks. During the follow-up period (mean +/- SD 8.1 +/- 1.8 years), 225 deaths due to pancreatic cancer were identified. Overall, neither alcohol nor coffee intake was associated with risk of death from pancreatic cancer. Heavy coffee consumption (> or =4 cups/day), however, may increase the risk. Men who reported a history of diabetes mellitus and women who reported a history of gallstone/cholecystitis were at significantly (2-fold) increased risk of death from pancreatic cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alcohol Drinking / adverse effects*
  • Cholecystitis / complications
  • Cholelithiasis / complications
  • Coffee / adverse effects*
  • Cohort Studies
  • Diabetes Complications
  • Female
  • Humans
  • Japan / epidemiology
  • Life Style
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / etiology
  • Pancreatic Neoplasms / mortality*
  • Proportional Hazards Models
  • Risk Factors
  • Sex Characteristics
  • Surveys and Questionnaires

Substances

  • Coffee