BAFF is a survival and maturation factor for mouse B cells

Eur J Immunol. 2002 Jul;32(7):2004-10. doi: 10.1002/1521-4141(200207)32:7<2004::AID-IMMU2004>3.0.CO;2-5.


Human B cell-activating factor (BAFF) induces mouse surface IgM+ B cells of the immature type from bone marrow and of the immature types 1 and 2 from spleen, as well as of the mature type from spleen to increased longevity in tissue culture. BAFF does so polyclonally and without inducing proliferation in any of these B cell subpopulations. BAFF induces phenotypic and functional maturation of immature to mature B cells so that all immature cells loose C1qRp (AA4.1, 493) expression and type 1 immature cells up-regulate IgD, CD21 and CD23. Immature B cells of types 1 and 2, upon pre-incubation with BAFF, change their reactiveness to Ig-specific antibodies so that they no longer enter apoptosis but now proliferate. However, BAFF does not seem to overcome negative selection of developing immature B cells in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Cell Activating Factor
  • B-Lymphocytes / cytology
  • B-Lymphocytes / drug effects*
  • B-Lymphocytes / immunology
  • Cell Differentiation / drug effects
  • Cell Division
  • Cell Survival / drug effects
  • Cells, Cultured
  • Humans
  • Membrane Proteins / pharmacology*
  • Mice
  • Mice, Inbred C57BL
  • Tumor Necrosis Factor-alpha / pharmacology*


  • B-Cell Activating Factor
  • Membrane Proteins
  • TNFSF13B protein, human
  • Tnfsf13b protein, mouse
  • Tumor Necrosis Factor-alpha