doi: 10.1002/jmv.10074.
Transforming growth factor-beta enhances human T-cell leukemia virus type I infection
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- PMID: 12116037
- DOI: 10.1002/jmv.10074
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Transforming growth factor-beta enhances human T-cell leukemia virus type I infection
J Med Virol.
2002 Jul.
Abstract
Human T-cell leukemia virus type I (HTLV-I), the causative agent of adult T-cell leukemia/lymphoma, is transmitted vertically by breast milk and sexually by semen. The transforming growth factor-beta (TGF-beta), a pleiotropic cytokine that is abundant in breast milk and semen, facilitates replication of HTLV-I in lymphocytes derived from asymptomatic HTLV-I carriers and transmission to cord blood lymphocytes in vitro. Transient expression assays revealed that TGF-beta can transactivate HTLV-I long terminal repeat promoter. These results suggest that TGF-beta may play a role in replication and transmission of HTLV-I.
Copyright 2002 Wiley-Liss, Inc.
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