Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits

Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1225-31. doi: 10.1161/01.atv.0000020676.11586.f2.

Abstract

Objective: This study evaluates the effect of a Curcuma longa extract on the development of experimental atherosclerosis (fatty streak) in rabbits and its interaction with other plasmatic antioxidants.

Methods and results: Two experimental groups of male New Zealand White rabbits, a control group and a curcuma-extract (CU) group, were fed an atherogenic diet. Additionally, the CU group received an oral curcuma hydroalcoholic extract. Six animals from each experimental group were killed after 10, 20, and 30 days. Compared with the CU group, the control group showed significantly higher plasma lipid peroxide at all experimental times (10, 20, and 30 days) and significantly lower alpha-tocopherol and coenzyme Q levels at 20 and 30 days. Histological results for the fatty streak lesions revealed damage in the thoracic and abdominal aorta that was significantly lower in the CU group than in the control group at 30 days.

Conclusions: Supplementation with Curcuma longa reduces oxidative stress and attenuates the development of fatty streaks in rabbits fed a high cholesterol diet.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / metabolism
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antioxidants / pharmacology
  • Aortic Diseases / prevention & control*
  • Arteriosclerosis / prevention & control*
  • Coenzymes
  • Coumaric Acids / chemistry
  • Coumaric Acids / pharmacology
  • Curcuma / chemistry*
  • Curcuma / metabolism
  • Curcumin / analogs & derivatives*
  • Curcumin / chemistry
  • Curcumin / metabolism
  • Curcumin / pharmacology
  • Diarylheptanoids
  • Diet, Atherogenic*
  • Dietary Supplements*
  • Lipid Peroxides / blood
  • Lipoproteins, LDL / blood
  • Male
  • Oxidative Stress / drug effects*
  • Plant Extracts / therapeutic use
  • Rabbits
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / blood
  • Vitamin A / blood
  • alpha-Tocopherol / blood

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Coenzymes
  • Coumaric Acids
  • Diarylheptanoids
  • Lipid Peroxides
  • Lipoproteins, LDL
  • Plant Extracts
  • oxidized low density lipoprotein
  • Vitamin A
  • Ubiquinone
  • bis(4-hydroxycinnamoyl)methane
  • coenzyme Q10
  • alpha-Tocopherol
  • Curcumin
  • demethoxycurcumin