Humming greatly increases nasal nitric oxide
- PMID: 12119224
- DOI: 10.1164/rccm.200202-138BC
Humming greatly increases nasal nitric oxide
Abstract
The paranasal sinuses are major producers of nitric oxide (NO). We hypothesized that oscillating airflow produced by humming would enhance sinus ventilation and thereby increase nasal NO levels. Ten healthy subjects took part in the study. Nasal NO was measured with a chemiluminescence technique during humming and quiet single-breath exhalations at a fixed flow rate. NO increased 15-fold during humming compared with quiet exhalation. In a two-compartment model of the nose and sinus, oscillating airflow caused a dramatic increase in gas exchange between the cavities. Obstruction of the sinus ostium is a central event in the pathogenesis of sinusitis. Nasal NO measurements during humming may be a useful noninvasive test of sinus NO production and ostial patency. In addition, any therapeutic effects of the improved sinus ventilation caused by humming should be investigated.
Comment in
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The paranasal sinuses and a unique role in airway nitric oxide production?Am J Respir Crit Care Med. 2002 Jul 15;166(2):131-2. doi: 10.1164/rccm.2205014. Am J Respir Crit Care Med. 2002. PMID: 12119221 No abstract available.
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