Common perinatal insults diminish cord blood RANTES

Biol Neonate. 2002;82(1):70-2. doi: 10.1159/000064156.

Abstract

We demonstrate that the cord blood RANTES concentrations are reduced in full-term newborns who were born from meconium-stained amniotic fluid as compared with full-term newborns born after normal delivery. Since RANTES inhibits immunodeficiency virus (HIV) entry into macrophages, thereby bestowing increased resistance to HIV (including protection in utero), we propose that common perinatal events might precipitate higher perinatal transmission of HIV.

MeSH terms

  • Amniotic Fluid*
  • Chemokine CCL2 / blood
  • Chemokine CCL5 / blood*
  • Female
  • Fetal Blood / metabolism*
  • Humans
  • Infant, Newborn
  • Interleukin-8 / blood
  • Meconium*
  • Pregnancy
  • Prospective Studies

Substances

  • Chemokine CCL2
  • Chemokine CCL5
  • Interleukin-8