Metabonomics: a platform for studying drug toxicity and gene function

Nat Rev Drug Discov. 2002 Feb;1(2):153-61. doi: 10.1038/nrd728.


The later that a molecule or molecular class is lost from the drug development pipeline, the higher the financial cost. Minimizing attrition is therefore one of the most important aims of a pharmaceutical discovery programme. Novel technologies that increase the probability of making the right choice early save resources, and promote safety, efficacy and profitability. Metabonomics is a systems approach for studying in vivo metabolic profiles, which promises to provide information on drug toxicity, disease processes and gene function at several stages in the discovery-and-development process.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Design
  • Drug Industry
  • Genes / physiology*
  • Genomics*
  • Humans
  • Kidney / drug effects
  • Liver / drug effects
  • Magnetic Resonance Spectroscopy
  • Toxicology / methods*