Hereditary pancreatitis in Japan: a review of pancreatitis-associated gene mutations

Pancreatology. 2001;1(5):444-7. doi: 10.1159/000055845.


Pancreatitis-associated gene mutations have been reported in patients with hereditary pancreatitis and idiopathic pancreatitis in the Caucasian population and involve the cationic trypsinogen gene, the pancreatic secretory trypsin inhibitor gene and the cystic fibrosis transmembrane conductance regulator gene. In the Japanese population, mutational screening analyses of these genes have shown several mutations. The present study reviews previous reports from Japan in order to evaluate the racial specificity of pancreatitis-associated gene mutations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Humans
  • Japan / epidemiology
  • Mutation / genetics*
  • Pancreatitis / epidemiology
  • Pancreatitis / genetics*
  • Trypsin Inhibitor, Kazal Pancreatic / genetics
  • Trypsin*
  • Trypsinogen / genetics


  • CFTR protein, human
  • PRSS2 protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Trypsin Inhibitor, Kazal Pancreatic
  • Trypsinogen
  • Trypsin