Cell fusion: an EFFicient sculptor

Curr Biol. 2002 Jul 9;12(13):R467-9. doi: 10.1016/s0960-9822(02)00948-x.

Abstract

Mutations in the eff-1 gene of Caenorhabditis elegans, which prevent all cell-cell fusions in the nematode's epidermis, have revealed developmental roles for cell fusion. An extracellular fusogen-like domain in EFF-1 suggests it might direct the fusion of lipid bilayers.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism*
  • Membrane Fusion / physiology*
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • EFF-1 protein, C elegans
  • Membrane Glycoproteins