Further checkpoints in Th1 development

Immunity. 2002 Jun;16(6):755-8. doi: 10.1016/s1074-7613(02)00331-x.


Tight control of Th1 immunity is essential to prevent immunopathology. Central to control of the IFN-gamma gene is the transcription factor T-bet, whose induction is Stat-1 dependent. IL-12 is dominant in directing Th1 development, while synergizing with IL-18 for IFNgamma production from differentiated Th1 cells. In this issue of Immunity, IL-27 is described, which acts in synergy with IL-12 early in Th1 development from naive T cells via the receptor TCCR/WSX-1. We review the coordination of these checkpoints in Th1 development and function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Glycoproteins / physiology*
  • Humans
  • Interleukin-12 / physiology*
  • Interleukin-18 / physiology*
  • Interleukins / physiology*
  • Minor Histocompatibility Antigens
  • Models, Biological
  • Receptors, Cytokine*
  • Th1 Cells / immunology*


  • EBI3 protein, human
  • Glycoproteins
  • Interleukin-18
  • Interleukins
  • MYDGF protein, human
  • Minor Histocompatibility Antigens
  • Receptors, Cytokine
  • Interleukin-12