Central role of peroxisomes in isoprenoid biosynthesis

Prog Lipid Res. 2002 Sep;41(5):369-91. doi: 10.1016/s0163-7827(02)00002-4.


Peroxisomes contain enzymes catalyzing a number of indispensable metabolic functions mainly related to lipid metabolism. The importance of peroxisomes in man is stressed by the existence of genetic disorders in which the biogenesis of the organelle is defective, leading to complex developmental and metabolic phenotypes. The purpose of this review is to emphasize some of the recent findings related to the localization of cholesterol biosynthetic enzymes in peroxisomes and to discuss the impairment of cholesterol biosynthesis in peroxisomal deficiency diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acyl Coenzyme A / metabolism
  • Cholesterol / biosynthesis
  • Disease Models, Animal
  • Embryonic and Fetal Development
  • Humans
  • Peroxisomal Disorders / embryology
  • Peroxisomal Disorders / metabolism*
  • Peroxisomes / enzymology
  • Peroxisomes / physiology*
  • Polyisoprenyl Phosphates / biosynthesis
  • Sesquiterpenes


  • Acyl Coenzyme A
  • Polyisoprenyl Phosphates
  • Sesquiterpenes
  • acetoacetyl CoA
  • farnesyl pyrophosphate
  • Cholesterol