Activities of ABT-773 against microaerophilic and fastidious organisms

Sydney M Finegold; Denise Molitoris; V T Phan; M-L Vaisanen; Hannah M Wexler

doi:10.1128/AAC.46.8.2716-2719.2002

Activities of ABT-773 against microaerophilic and fastidious organisms

Antimicrob Agents Chemother. 2002 Aug;46(8):2716-9. doi: 10.1128/AAC.46.8.2716-2719.2002.

Authors

Sydney M Finegold¹, Denise Molitoris, V T Phan, M-L Vaisanen, Hannah M Wexler

Affiliation

¹ Infectious Diseases Section, VA Greater Los Angeles Healthcare System, West Los Angeles Division, Los Angeles, CA 90073, USA. sidfinegol@aol.com

Abstract

ABT-773 was tested against 317 fastidious isolates; it inhibited 99% of organisms at a concentration of 4.0 microg/ml. With ampicillin-sulbactam and levofloxacin, only 2 and 6% of these strains, respectively, were resistant at the breakpoint. With clindamycin, penicillin G, and metronidazole, 22, 26, and 58% of the strains, respectively, were resistant.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects*
Drug Resistance, Microbial
Erythromycin / analogs & derivatives*
Erythromycin / pharmacology*
Ketolides*
Microbial Sensitivity Tests

Substances

Anti-Bacterial Agents
Ketolides
Erythromycin
cethromycin