Medical therapy for ulcerative colitis

Gastroenterol Clin North Am. 2002 Mar;31(1):147-66. doi: 10.1016/s0889-8553(01)00010-3.


Although newer therapeutic agents are being developed for the treatment of inflammatory bowel disease, aminosalicylates and corticosteroids remain the mainstay of treatment for UC (Tables 2-5). Patients who do not respond to these agents or become steroid dependent require immunomodulatory therapy or curative surgery. Cyclosporine represents the greatest treatment advance for UC in 10 years. The role of nicotine, heparin, antibiotics, probiotics, and SCFA in the treatment of UC is less clear, but these agents may offer an alternative therapeutic approach for patients intolerant or nonresponsive to standard therapy.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic / therapeutic use
  • Adrenal Cortex Hormones / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Colitis, Ulcerative / drug therapy*
  • Humans


  • Adjuvants, Immunologic
  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents