Rational and targeted pharmacologic treatment of fibromyalgia

Rheum Dis Clin North Am. 2002 May;28(2):261-90. doi: 10.1016/s0889-857x(01)00011-4.


Despite disappointing results when subjected to randomized clinical trials, pharmacologic agents remain an important component of FM management. Addressing the main symptoms of pain, disturbed sleep, mood disturbances, fatigue, and associated conditions is essential to improve patient functioning and enhanced quality of life. However, much work remains to design clinical trials which address the complexity of FM, while satisfying evidence based medicine paradigms.

Publication types

  • Review

MeSH terms

  • Fatigue / drug therapy
  • Fatigue / etiology
  • Fibromyalgia / complications
  • Fibromyalgia / drug therapy*
  • Humans
  • Mood Disorders / drug therapy
  • Mood Disorders / etiology
  • Sleep Wake Disorders / drug therapy
  • Sleep Wake Disorders / etiology