Cadherins communicate structural plasticity of presynaptic and postsynaptic terminals

Neuron. 2002 Jul 3;35(1):1-3. doi: 10.1016/s0896-6273(02)00765-1.

Abstract

Synapse adhesion molecules play a key role in specifying and facilitating the recognition of axodendritic contacts. New studies by and reported in this issue of Neuron reveal multiple functions for the cadherin-catenin complex. This adhesion complex regulates synaptogenesis and coordinates synaptic strength with presynaptic and postsynaptic organization, including the shape of dendritic spines.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Cadherins / metabolism*
  • Cell Adhesion / physiology*
  • Central Nervous System / growth & development*
  • Central Nervous System / metabolism
  • Central Nervous System / ultrastructure
  • Cytoskeletal Proteins / metabolism
  • Dendrites / metabolism*
  • Dendrites / ultrastructure
  • Humans
  • Neuronal Plasticity / physiology*
  • Presynaptic Terminals / metabolism*
  • Presynaptic Terminals / ultrastructure
  • Synaptic Transmission / physiology*
  • Trans-Activators*
  • beta Catenin

Substances

  • CTNNB1 protein, human
  • Cadherins
  • Cytoskeletal Proteins
  • Trans-Activators
  • beta Catenin