EGF receptor activation by heterologous mechanisms

Cancer Cell. 2002 Jun;1(5):405-6. doi: 10.1016/s1535-6108(02)00076-4.


A myriad of growth factor-dependent and -independent mechanisms for activating the EGF receptor and the related ErbB receptors underscore the importance of receptor inhibitors in the treatment of some solid tumors.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism
  • ErbB Receptors / metabolism*
  • Female
  • Humans
  • Receptors, Cell Surface / metabolism*
  • Receptors, Urokinase Plasminogen Activator
  • Signal Transduction / physiology*
  • Up-Regulation


  • PLAUR protein, human
  • Receptors, Cell Surface
  • Receptors, Urokinase Plasminogen Activator
  • ErbB Receptors