This is the second of two papers each dealing with a specific technological option for replacing the Fenton's reagent with simpler processes for treating industrial wastewater. In particular, the paper reports the results of an investigation aimed to check, at lab scale, the effectiveness of an alternative wastewater treatment combining biological degradation and chemical oxidation with ozone. The treatment was carried out in a lab scale hybrid reactor fed with the biological stage effluent of a plant treating the wastewater of a large tanning district in Central Italy whose residual COD result still higher than the Italian COD Maximum Allowable Concentration (MAC) value (i.e., 160 mgO2/L) The results are very promising, considering that a removal efficiency of 41% (as COD) has been achieved by treating an influent characterized by a COD content fully biorefractory. In addition, the proposed treatment presents the significant advantage of no additional sludge production, as happens with commonly utilized tertiary processes (i.e. Fenton), that is characterized by high chemical sludge production.