Granulomatous angiitis of the central nervous system associated with herpes zoster

J Assoc Physicians India. 2002 Jul;50:977-8.


Granulomatous angiitis of central nervous system (CNS) is a rare inflammatory disease of blood vessels mostly confined to CNS. We describe a case which presented with right sided hemiplegia with aphasia, after herpes zoster ophthalmicus. CT scan and MRI brain showed a large left sided infarct in the left middle cerebral artery (MCA) territory. MRI angiography revealed narrowing and thinning of left internal carotid artery (ICA) and to a lesser extent, left MCA suggestive of granulomatous vasculitis. Herpes zoster is often associated with major CNS involvement and a vascular etiology was previously postulated. Recent pathological reports suggest that cerebral angiitis secondary to herpes virus infection may be more common than realised.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Central Nervous System Diseases / complications
  • Central Nervous System Diseases / diagnosis
  • Central Nervous System Diseases / virology
  • Cerebral Arteries / pathology*
  • Hemiplegia / etiology*
  • Hemiplegia / virology*
  • Herpes Zoster Ophthalmicus / complications*
  • Humans
  • Male
  • Vasculitis, Central Nervous System / pathology*