Gastroprotective effect of fenugreek seeds (Trigonella foenum graecum) on experimental gastric ulcer in rats

J Ethnopharmacol. 2002 Aug;81(3):393-7. doi: 10.1016/s0378-8741(02)00117-4.


The effect of fenugreek seeds (Trigonella foenum graecum) compared to omeprazole was studied on ethanol-induced gastric ulcer. The aqueous extract and a gel fraction isolated from the seeds showed significant ulcer protective effects. The cytoprotective effect of the seeds seemed to be not only due to the anti-secretory action but also to the effects on mucosal glycoproteins. The fenugreek seeds also prevented the rise in lipid peroxidation induced by ethanol presumably by enhancing antioxidant potential of the gastric mucosa thereby lowering mucosal injury. Histological studies revealed that the soluble gel fraction derived from the seeds was more effective than omeprazole in preventing lesion formation. These observations show that fenugreek seeds possess antiulcer potential.

MeSH terms

  • Animals
  • Ethanol / pharmacology
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology
  • Hydrochloric Acid / pharmacology
  • Lipid Peroxidation / drug effects
  • Omeprazole / pharmacology
  • Omeprazole / therapeutic use
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar
  • Seeds / chemistry*
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / metabolism
  • Stomach Ulcer / pathology
  • Stomach Ulcer / prevention & control*
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Trigonella / chemistry*


  • Plant Extracts
  • Thiobarbituric Acid Reactive Substances
  • Ethanol
  • Omeprazole
  • Hydrochloric Acid