Abstract
The synthesis of a series of 3-aryl pyrazolo[4,3-d]pyrimidines as potential corticotropin-releasing factor (CRF-1) antagonists is described. The effects of substitution on the aromatic ring, the amino group and the pyrazolo ring on CRF-1 receptor binding were investigated.
MeSH terms
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Binding Sites
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Drug Design*
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Molecular Structure
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Pyrimidines / chemical synthesis*
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Pyrimidines / chemistry
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Pyrimidines / pharmacology*
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Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Pyrimidines
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Receptors, Corticotropin-Releasing Hormone
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CRF receptor type 1