Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays

Cancer Lett. 2002 Oct 28;184(2):197-206. doi: 10.1016/s0304-3835(02)00197-0.


To identify genes whose alterations lead to gastric cancer, gene expression profiles have been obtained from 22 gastric cancer tissues and their surrounding gastric mucosa tissues. A total of 16 genes were differentially expressed in more than 50% of gastric cancer tissues compared with surrounding gastric mucosa tissues. Genes such as HMG-Y, fibroblast collagenase inhibitor, and osteopontin are among those that are overexpressed in over 50% of the gastric cancer tissues. Dihydrodiol dehydrogenase, ribonuclease A, and glutathione peroxidase are among those genes that are underexpressed in over 50% of the gastric cancer tissues. We identified genes that are associated with clinical phenotypes of patients with gastric cancers. Alpha-II spectrin, Na/K-ATPase and KIAA0111 are those that are enhanced in intestinal type of gastric cancer. Gene such as platelet-endothelial tetraspan antigen 3 was enhanced in highly metastatic gastric cancer tissues.

Publication types

  • Comparative Study

MeSH terms

  • Base Sequence
  • DNA Primers
  • DNA, Complementary
  • Gastric Mucosa / metabolism*
  • Gastric Mucosa / pathology
  • Gene Expression Regulation*
  • Gene Expression Regulation, Neoplastic*
  • Glutathione Peroxidase / genetics
  • HMGA1a Protein / genetics
  • Humans
  • Oligonucleotide Array Sequence Analysis*
  • Osteopontin
  • Oxidoreductases / genetics
  • Phenotype
  • Regression Analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ribonuclease, Pancreatic / genetics
  • Sialoglycoproteins / genetics
  • Sodium-Potassium-Exchanging ATPase / genetics
  • Spectrin / genetics
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / surgery


  • DNA Primers
  • DNA, Complementary
  • SPP1 protein, human
  • Sialoglycoproteins
  • Osteopontin
  • HMGA1a Protein
  • Spectrin
  • Oxidoreductases
  • Glutathione Peroxidase
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
  • Ribonuclease, Pancreatic
  • Sodium-Potassium-Exchanging ATPase