Smad7: a new key player in TGF-beta-associated disease

Trends Mol Med. 2002 Aug;8(8):361-3. doi: 10.1016/s1471-4914(02)02376-6.


Smad7 is a major inhibitory regulator of transforming growth factor (TGF)-beta signaling. Smad7 expression is induced by TGF-beta itself and other signaling pathways, indicating a key role for Smad7 in feedback or cross-talk control of TGF-beta signaling. Recent reports have implicated Smad7 as a crucial regulator of TGF-beta activity in human disease; aberrant expression of Smad7 is involved in inflammatory bowel disease and scleroderma. Thus, modulation of Smad7 expression could provide a novel therapeutic basis for TGF-beta-associated disorders.

Publication types

  • News

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Inflammatory Bowel Diseases / metabolism*
  • Models, Biological
  • Scleroderma, Systemic / metabolism*
  • Signal Transduction / physiology*
  • Smad7 Protein
  • Trans-Activators / genetics
  • Trans-Activators / metabolism*
  • Transforming Growth Factor beta / metabolism*


  • DNA-Binding Proteins
  • SMAD7 protein, human
  • Smad7 Protein
  • Trans-Activators
  • Transforming Growth Factor beta