Abstract
The mechanism that allows a neuron to send cues received at its terminal to its cell body and nucleus has proved elusive. However, a recent study by Howe and colleagues indicates that neurotrophin signaling via the trkA receptor requires formation of a signaling endosome containing NGF and trkA. Thus, endocytosis of the neurotrophin-receptor complex is a crucial step in the generation of intracellular signaling platforms required for activation and compartmentalization of signaling events.
MeSH terms
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Animals
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Clathrin / metabolism
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Endocytosis / physiology*
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Endosomes / metabolism*
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Endosomes / ultrastructure
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Humans
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Mitogen-Activated Protein Kinases / metabolism
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Nerve Growth Factor / metabolism*
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Nerve Growth Factors / metabolism*
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Nervous System / cytology
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Nervous System / metabolism*
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Presynaptic Terminals / metabolism*
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Presynaptic Terminals / ultrastructure
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Receptor, trkA / metabolism*
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Signal Transduction / physiology*
Substances
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Clathrin
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Nerve Growth Factors
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Nerve Growth Factor
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Receptor, trkA
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Mitogen-Activated Protein Kinases