A quantitative evaluation of anticoagulants in experimental nephrotoxic nephritis

Clin Exp Immunol. 1975 Feb;19(2):301-8.

Abstract

The protective effects of anticoagulants in nephrotoxic nephritis in rabbits have been studied, using various doses of heparin and defibrination with ancrod. Massive doses of heparin (2000 units/kg/day) were required before significant reduction in glomerular fibrin deposition, extracepillary cell proliferation and urea retention occurred. Doses of 300 and 1000 units/kg/day were insufficient to modify fibrin deposition and cell proliferation. Defibrination with ancrod provided protection, judged by histological and functional criteria, comparable to 2000 units of heparin/kg/day; but fibrin could still be demonstrated in the glomeruli of animals treated with 2000 units of heparin/kg/day, contrasting with the virtual absence of fibrin in animals given ancrod.

Publication types

  • Comparative Study

MeSH terms

  • Ancrod / therapeutic use*
  • Animals
  • Basement Membrane / immunology
  • Blood Coagulation Tests
  • Complement C3
  • Dose-Response Relationship, Drug
  • Endopeptidases / therapeutic use*
  • Fibrin / analysis
  • Heparin / therapeutic use*
  • Immunoglobulin G
  • Kidney Glomerulus / analysis
  • Male
  • Nephritis / drug therapy*
  • Nephritis / immunology
  • Rabbits

Substances

  • Complement C3
  • Immunoglobulin G
  • Fibrin
  • Heparin
  • Endopeptidases
  • Ancrod