Liver injury after beginning antiretroviral therapy in HIV/hepatitis C virus co-infected patients is not related to immune reconstitution

AIDS. 2002 Jul 5;16(10):1423-5. doi: 10.1097/00002030-200207050-00016.


Transaminase elevations occur more frequently after beginning antiretroviral therapy in HIV-positive patients co-infected with hepatitis C virus (HCV). The mechanism of liver injury in these individuals is unknown, although immune reconstitution phenomena have been postulated. In 42 HIV/HCV co-infected individuals followed after beginning potent antiretroviral therapy, the development of liver injury was not associated with significant changes in serum HCV-RNA levels nor with greater CD4 cell increases. Underlying chronic hepatitis may thus increase the risk of liver toxicity by other mechanisms.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active / adverse effects
  • CD4 Lymphocyte Count
  • Chemical and Drug Induced Liver Injury / etiology
  • Female
  • HIV Infections / blood
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • Hepatitis C / complications*
  • Hepatitis C / virology
  • Humans
  • Male
  • RNA, Viral / blood
  • Retrospective Studies
  • Viral Load
  • Viremia


  • Anti-HIV Agents
  • RNA, Viral