A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol, and 2% aqueous chlorhexidine

J Infus Nurs. Jul-Aug 2002;25(4):244-9. doi: 10.1097/00129804-200207000-00007.

Abstract

ChloraPrep (2% chlorhexidine gluconate + 70% isopropyl alcohol [CHG + IPA] in a 3.0-mL applicator) is a recently approved antiseptic for preoperative skin preparation. This controlled open-label trial assessed the immediate and persistent antimicrobial efficacy and safety of CHG + IPA compared with 70% IPA or a 2% CHG aqueous solution alone. Each antiseptic significantly reduced abdominal and inguinal microbial counts from baseline at 10 minutes, 6 hours, and 24 hours (P =.0001). CHG + IPA provided significantly more persistent antimicrobial activity on abdominal sites than IPA (P =.003) or CHG (P =.028) at 24 hours. No skin irritations were reported for any of the three antiseptics.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • 2-Propanol / pharmacology*
  • Adult
  • Aged
  • Anti-Infective Agents, Local / pharmacology*
  • Chlorhexidine / analogs & derivatives*
  • Chlorhexidine / pharmacology*
  • Colony Count, Microbial
  • Cross Infection / prevention & control
  • Dermatologic Agents / pharmacology*
  • Drug Combinations
  • Humans
  • Middle Aged
  • Preoperative Care
  • Skin / microbiology*
  • Statistics, Nonparametric

Substances

  • Anti-Infective Agents, Local
  • Dermatologic Agents
  • Drug Combinations
  • chlorhexidine gluconate
  • 2-Propanol
  • Chlorhexidine