Abstract
A 57-year-old man showed high serum cortisol, plasma adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) levels with a large pituitary tumor and a prostatic cancer. High dose dexamethasone did not suppress cortisol secretion and CRH administration did not stimulate cortisol secretion. After surgical removal of the pituitary tumor, plasma CRH, ACTH and serum cortisol levels were normalized. Histological examinations showed pituitary adenoma and prostatic adenocarcinoma, and pituitary adenoma was stained with both anti-CRH and anti-ACTH antibodies, but prostatic cancer was not stained. A CRH-producing pituitary adenoma is a new type of Cushing's syndrome.
MeSH terms
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Adenocarcinoma / complications
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Adenoma / complications
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Adenoma / diagnosis*
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Adenoma / metabolism*
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Adenoma / surgery
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Adrenocorticotropic Hormone / biosynthesis*
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Adrenocorticotropic Hormone / blood
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Corticotropin-Releasing Hormone / biosynthesis*
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Corticotropin-Releasing Hormone / blood
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Cushing Syndrome / diagnosis*
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Cushing Syndrome / etiology*
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Cushing Syndrome / surgery
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Dexamethasone
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Glucocorticoids
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Humans
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Hydrocortisone / blood
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Hypophysectomy
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Pituitary Neoplasms / complications
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Pituitary Neoplasms / diagnosis*
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Pituitary Neoplasms / metabolism*
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Pituitary Neoplasms / surgery
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Pituitary-Adrenal Function Tests
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Prostatic Neoplasms / complications
Substances
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Glucocorticoids
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Dexamethasone
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Adrenocorticotropic Hormone
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Corticotropin-Releasing Hormone
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Hydrocortisone