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Clinical Trial
, 6 (3), 251-9

Physiological-dose Steroid Therapy in Sepsis [ISRCTN36253388]

Clinical Trial

Physiological-dose Steroid Therapy in Sepsis [ISRCTN36253388]

Orhan Yildiz et al. Crit Care.


Introduction: The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin, and to determine the effects of physiological dose steroid therapy on mortality in patients with sepsis.

Methods: Basal cortisol level and corticotropin stimulation test were performed within 24 hours in all patients. One group (20 patients) received standard therapy for sepsis and physiological-dose steroid therapy for 10 days; the other group (20 patients) received only standard therapy for sepsis. Basal cortisol level was measured on the 14th day in patients who recovered. The outcome of sepsis was compared.

Results: Only Sequential Organ Failure Assessment (SOFA) score was found related to mortality, independent from other factors in multivariate analysis. No significant difference was found between the changes in the percentage of SOFA scores of the steroid therapy group and the standard therapy group in survivors, nor between the groups in basal and peak cortisol levels, cortisol response to corticotropin test and mortality. The mortality rates among patients with occult adrenal insufficiencies were 40% in the steroid therapy group and 55.6% in the standard therapy group.

Discussion: There was a trend towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy. In the advancing process from sepsis to septic shock, adrenal insufficiency was not frequent as supposed. There was a trend (that did not reach significance) towards a decrease in the mortality rates of the patients with sepsis who received physiological-dose steroid therapy.


Figure 1
Figure 1
Comparison of mortality rates for (a) basal cortisol (μg/dl), (b) cortisol response to ACTH (μg/dl), (c) APACHE II and (d) maximum SOFA scores in both groups.

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    1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest. 1992;101:1644–1655. - PubMed
    1. Centers for Disease Control Increase in national hospital discharge survey rates for septicemia – United States, 1979–1987. JAMA. 1990;263:937–938. - PubMed
    1. Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med. 2001;29:S109–S116. - PubMed
    1. Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl JMed. 1999;340:207–214. - PubMed
    1. Natanson C, Hofmann WD, Suffredini AF, Eichacker PQ, Danner RL. Selected treatment strategies for septic shock based on proposed mechanism of pathogenesis. Ann Intern Med. 1994;120:771–783. - PubMed

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