Protein flexibility and drug design: how to hit a moving target

Curr Opin Chem Biol. 2002 Aug;6(4):447-52. doi: 10.1016/s1367-5931(02)00341-1.


The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Computer Simulation
  • Databases, Protein
  • Drug Design*
  • Humans
  • Protein Binding
  • Protein Conformation
  • Proteins / chemistry*


  • Proteins