Abstract
Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Base Sequence
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DNA, Viral / genetics
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Herpesvirus 3, Human / pathogenicity*
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Herpesvirus 3, Human / physiology*
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Humans
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Liver / virology
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Liver Transplantation
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Mice
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Mice, SCID
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Polymerase Chain Reaction
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Sequence Deletion
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Skin / virology*
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T-Lymphocytes / virology*
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Thymus Gland / transplantation
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Thymus Gland / virology
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Transplantation, Heterologous
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Viral Envelope Proteins / physiology*
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Virulence
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Virus Replication / physiology
Substances
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DNA, Viral
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Viral Envelope Proteins
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glycoprotein E, varicella-zoster virus