Glutamate release during LTD at cerebellar climbing fiber-Purkinje cell synapses

Nat Neurosci. 2002 Aug;5(8):725-6. doi: 10.1038/nn895.


It is widely thought that persistent, use-dependent alterations in synaptic strength such as long-term synaptic potentiation (LTP) and depression (LTD) underlie at least a portion of memory traces in the brain, but the exact cellular locus of expression for these alterations remains to be determined. They could be expressed presynaptically as a decrease in transmitter release, postsynaptically as a decrease in the synaptic current evoked by a fixed delivery of transmitter, as an increase in the number of functional synaptic contacts, or by a combination of these mechanisms. Here we report that LTD at the climbing fiber-Purkinje cell synapse in rat cerebellum was not associated with changes in a synaptic cleft glutamate transient, indicating that this type of LTD is most likely expressed postsynaptically.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cerebellum / cytology
  • Cerebellum / physiology*
  • Electric Stimulation
  • Excitatory Amino Acid Antagonists / pharmacology
  • Excitatory Postsynaptic Potentials / drug effects
  • Excitatory Postsynaptic Potentials / physiology
  • Glutamic Acid / metabolism*
  • In Vitro Techniques
  • Nerve Fibers / drug effects
  • Nerve Fibers / metabolism*
  • Neural Inhibition / physiology
  • Patch-Clamp Techniques
  • Purkinje Cells / drug effects
  • Purkinje Cells / metabolism*
  • Rats
  • Receptors, AMPA / antagonists & inhibitors
  • Synapses / drug effects
  • Synapses / metabolism*
  • Temperature
  • Time


  • Excitatory Amino Acid Antagonists
  • Receptors, AMPA
  • Glutamic Acid