Combination therapy of exercise and angiotensin-converting enzyme inhibitor markedly improves insulin sensitivities in hypertensive patients with insulin resistance

Circ J. 2002 Jul;66(7):655-8. doi: 10.1253/circj.66.655.


The contraction of muscle enhances the release of bradykinin (BK) and improves glucose uptake by the muscle. Angiotensin-converting enzyme inhibitor (ACEI) slows the breakdown of BK, thus the effect of BK is augmented in the presence of ACEI. The present study investigated whether the combination of exercise (increased production of BK) and ACEI (delay in breakdown of BK) might further improve insulin sensitivity in hypertensive patients with insulin resistance (HOMA-R>1.8). Patients were assigned either to increased walking distance (Walking group) or taking 2 mg temocapril, an ACEI, daily (ACEI group) for 8 weeks. Then both interventions were given to all patients for 8 weeks (ACEI+Walking group). Blood concentrations of triglycerides were slightly lower in the ACEI+Walking group than at baseline, although there were no significant differences in total cholesterol or high density lipoprotein-cholesterol among the 2 groups. Blood glucose was not significantly different with each treatment, but blood concentrations of insulin and HOMA-R were significantly lower in the Walking and ACEI groups compared with the Control group. The combination of walking and ACEI further lowered blood concentrations of insulin and HOMA-R, which suggests that this treatment is beneficial for hypertensive patients with insulin resistance.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Angiotensin-Converting Enzyme Inhibitors / administration & dosage*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Antihypertensive Agents / administration & dosage
  • Antihypertensive Agents / pharmacology
  • Blood Glucose
  • Blood Pressure
  • Combined Modality Therapy
  • Exercise Therapy*
  • Female
  • Humans
  • Hypertension / blood
  • Hypertension / etiology
  • Hypertension / therapy*
  • Insulin / blood
  • Insulin Resistance*
  • Lipids / blood
  • Male
  • Middle Aged
  • Thiazepines / administration & dosage
  • Thiazepines / pharmacology


  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Blood Glucose
  • Insulin
  • Lipids
  • Thiazepines
  • temocapril hydrochloride