IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts

Biochem Biophys Res Commun. 2002 Aug 2;295(5):1085-9. doi: 10.1016/s0006-291x(02)00809-4.


Caveolin 1, a component of caveolae, regulates signalling pathways compartmentalization interacting with tyrosine kinase receptors and their substrates. The role of caveolin 1 in the Insulin Receptor (IR) signalling has been well investigated. On the contrary, the functional link between caveolin 1 and IGF-I Receptor (IGF-IR) remains largely unknown. Here we show that (1) IGF-IR colocalizes with caveolin 1 in the lipid rafts enriched fractions on plasmamembrane in R-IGF-IR(WT) cells, (2) IGF-I induces caveolin 1 phosphorylation at the level of tyrosine 14, (3) this effect is rapid and results in the translocation of caveolin 1 and in the formation of membrane patches on cell surface. These actions are IGF-I specific since we did not detect caveolin 1 redistribution in insulin stimulated R(-) cells overexpressing IRs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Caveolin 1
  • Caveolins / metabolism*
  • Cells, Cultured
  • Insulin-Like Growth Factor I / metabolism*
  • Membrane Microdomains / metabolism*
  • Mice
  • Phosphorylation
  • Transfection


  • Cav1 protein, mouse
  • Caveolin 1
  • Caveolins
  • Insulin-Like Growth Factor I