New disguises for an old channel: MaxiK channel beta-subunits

News Physiol Sci. 2002 Aug;17:156-61. doi: 10.1152/nips.01387.2002.

Abstract

Ca(2+)-activated K(+) channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory b-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromaffin Cells / chemistry
  • Chromaffin Cells / physiology
  • Cochlea / chemistry
  • Cochlea / physiology
  • Large-Conductance Calcium-Activated Potassium Channels
  • Molecular Sequence Data
  • Muscle, Smooth / chemistry
  • Muscle, Smooth / physiology
  • Potassium Channels, Calcium-Activated / chemistry*
  • Potassium Channels, Calcium-Activated / physiology*
  • Protein Structure, Tertiary

Substances

  • Large-Conductance Calcium-Activated Potassium Channels
  • Potassium Channels, Calcium-Activated