Non-canonical Wnt signalling and regulation of gastrulation movements

Semin Cell Dev Biol. 2002 Jun;13(3):251-60. doi: 10.1016/s1084-9521(02)00052-6.


Members of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Gastrula / physiology*
  • Glycoproteins / metabolism
  • Ligands
  • Models, Biological
  • Mutation
  • Phenotype
  • Proto-Oncogene Proteins / metabolism*
  • Signal Transduction*
  • Wnt Proteins
  • Xenopus / embryology*
  • Xenopus Proteins
  • Zebrafish / embryology*
  • Zebrafish Proteins*


  • Glycoproteins
  • Ligands
  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Wnt11 protein, zebrafish
  • Xenopus Proteins
  • Zebrafish Proteins
  • wnt11b protein, Xenopus
  • wnt8b protein, zebrafish
  • Calcium