Abstract
Retrospective review of serum immunoglobulin levels in 78 methotrexate treated paediatric rheumatology patients showed that IgG, IgA, and IgM levels fell significantly by 26%, 21%, and 17% respectively while on methotrexate. Six patients with systemic disease showed a fall in IgG to below the normal range.
MeSH terms
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Antirheumatic Agents / pharmacology*
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Antirheumatic Agents / therapeutic use
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Arthritis, Juvenile / drug therapy*
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Arthritis, Juvenile / immunology
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Child
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Humans
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Immunoglobulin G / blood
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Immunoglobulin G / drug effects
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Immunoglobulins / blood
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Immunoglobulins / drug effects*
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Immunosuppressive Agents / pharmacology*
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Immunosuppressive Agents / therapeutic use
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Methotrexate / pharmacology*
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Methotrexate / therapeutic use
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Retrospective Studies
Substances
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Antirheumatic Agents
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Immunoglobulin G
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Immunoglobulins
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Immunosuppressive Agents
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Methotrexate